Does a high CA-125 always mean cancer? No, a high CA-125 does not always mean cancer is present. Generally speaking, the normal range of CA-125 is considered to be 0-35 units/mL, while a level above 35 units/mL is considered to be a high CA-125 level.
Can CA125 be high without cancer?
A rising CA 125 level may indicate a return or continued growth of the cancer. A number of normal and noncancerous conditions can cause an elevated CA 125 level, including: Endometriosis. Liver disease.
Can benign ovarian cysts cause elevated CA125?
Not necessarily. Elevated CA-125 (a protein in the blood thats associated with ovarian cancer) is most often caused by common, ordinary or benign conditions such as uterine fibroids, ovarian cysts, endometriosis — or even just having your period.
How often is CA125 elevated in ovarian cancer?
Serum CA125 levels are elevated in 50% of early-stage tumours, which are mostly type I ovarian cancers and 92% of advanced-stage tumours, which are mostly type II ovarian cancers [18,19].
How accurate is CA125 in detecting ovarian cancer?
Results: Using a CA125 cutoff of 30 U/mL, an overall sensitivity of 94.8% (96.6% specificity) was obtained when comparing malignancies versus healthy postmenopausal controls, whereas a cutoff of 65 U/mL provided a sensitivity of 83.9% (99.6% specificity).
What happens if CA125 high?
CA125 is produced by some ovarian cancer cells. A high level of CA125 in your blood could be a sign of ovarian cancer. But a raised CA125 level does not mean you definitely have cancer, as it can also be caused by other conditions such as endometriosis, fibroids and even pregnancy.
What are the signs of late stages of ovarian cancer?
Managing Advanced Ovarian Cancer SymptomsAbdominal pain.Constipation.Kidney pain.Bloating.Weight loss.Frequent urination.Ascites.